This book offers an overview on the growing field of nonhuman studies in relation to Anglophone novels. It illuminates the variety of nonhuman actors that take centre stage in the twenty-first-century novel and the formal changes that the Anthropocene, the digital turn, the animal rights movement, and research into plant consciousness have brought to the novel as a form. The book is divided into four sections, each focusing on a different aspect of twenty-first-century literature that engages with the nonhuman. The collection investigates how the environmental changes and the increasing use of AI technologies have fostered the flourishing of genres like the New Weird, Climate Fiction, and speculative fiction, how it makes us embrace new perceptions of life in relation to genetic engineering, and how it forces us to engage with newly emerging political contexts.